This was a while ago, but one time I decided to set up a Golden Deck with Ambassador and Possession on the board.
I know, horrible idea. I just wanted to try it, I was against an opponent who wasn't as good as me and had never set up the golden deck before.
Anyway, as expected, he started to Ambassador me junk. I would instead not buy a province and trash the junk he gave me. Then he started playing multiple Ambassadors... Enough to the point that he managed to Ambassador me an Ambassador, Possess my hand before I could trash it, and Ambassador my Bishop. I still won by quite a bit of points, but it was interesting doing it in such hard conditions...