I doubt there will be cards that care about order of the discard pile.
However, I could totally see "the discard pile" being a theme of Guilds, just like "the trash" was a theme of Dark Ages. We already have Counting House, Inn, Scavenger and Hermit - what else could play with the discard pile?
Also, I'm still waiting for an Attack Village (Dame Molly doesn't really count).