Disclaimer: I've been mostly a lurker on this site for a while. I only started playing Dominion at the end of last January, so I'm not that great of a player by any stretch. I didn't play on iso that much, and I don't really play on Goko that much either (but I want too....).
Anyway, my wife and I played a couple of Alchemy/Prosperity games last night, and we came across (in my mind) this really interesting board.
http://www.dominiondeck.com/games/big-or-small[Herbalist,Apothecary,Watchtower,Philosopher's Stone,Familiar,Talisman,Bishop,Mountebank,Apprentice,Hoard]
I had just read about the herbalist/phil stone combo a while ago, so that is what immediately jumped out at me, but the more I looked at the board the more I started seeing other viable strategies. I ended up trying the herbalist/phil stone combo, and pulled it off pretty well. My wife quickly filled me up with all 10 curses, and a bunch of coppers, which I was happy to count every time I played my phil stone. I ended up winning 35-29, which I think is pretty good considering I had all 10 curses, and some terrible luck with my phil stones and herbalists not lining up (despite the fact I had about 8 herbalists, and 4 phil stones).
As I said, I'm still fairly new, so I may have missed a few (maybe obvious) strategies.
Also, is there another board I should have posted this to? I looked but couldn't find any kind of "IRL game session" board.