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[mxdata]

Way of the Turtle + Conspirators is great. Just Turtle two Actions, and your Conspirators are automatically activated at the start of each turn, since doing Turtle every turn on an Action still counts as an Action. So, just Turtle away two cheap Actions and keep Turtling them every turn

[tim17]

merchant guild + stampede

Depends a bit on the board, but the plan goes something like this:

1. Get a merchant guild
2. Buy stampede with merchant guild in play
3. Play the horses to hopefully draw the merchant guild, use the coffers to hopefully buy multiple stampedes. Repeat
4. At some point, get another merchant guild (and a source of +actions to play them both), doubling the coffers you get from the stampedes
5. On the turn before you have enough coffers to empty the provinces, get as much +buy as you need
6. On your last turn, you can finally put more than 5 cards in play, since you don't need to stampede anymore

On some boards, there will be a faster engine, but if not, this combo can pretty much always work. It doesn't need trashing or other draw (and often can't even play them much anyway). All it needs is some source of +actions. Even without that, it can still do some things, but it needs the multiple merchant guilds to really explode.

[grrgrrgrr]

I'm not sure if this has already been brought up, but Trail + Way of the Mouse Workshop is absolutely nuts. The first player that hits $4 can get all 10 trails. In many instances, this is instant win.

[Erick648]

For that matter, Trail + Way of the Butterfly lets you gain $5 cards as though they cost $4.  For example, you can use a Workshop variant to gain Trail, then use Trail's reaction to play it and apply Butterfly to return it for a Laboratory. 

This also applies to Trails gained by Way of the Butterfly itself, letting you "double-upgrade" $3 Action cards.  For example, you can play a Horse from your hand, apply Butterfly to return it and gain a Trail, play the Trail using its reaction, and apply Butterfly to return it and gain a Laboratory.

[mxdata]

For that matter, Trail + Way of the Butterfly lets you gain $5 cards as though they cost $4.  For example, you can use a Workshop variant to gain Trail, then use Trail's reaction to play it and apply Butterfly to return it for a Laboratory. 

This also applies to Trails gained by Way of the Butterfly itself, letting you "double-upgrade" $3 Action cards.  For example, you can play a Horse from your hand, apply Butterfly to return it and gain a Trail, play the Trail using its reaction, and apply Butterfly to return it and gain a Laboratory.

Villa + Way of the Butterfly works the same way

[mxdata]

Citadel + Way of the Frog can be really strong as it allows you to play a single Action card non-terminally at the start of every turn, as long as you choose Frog for one of the two plays, similar to Prince, although with a few obvious differences

[emtzalex]

Citadel + Way of the Frog can be really strong as it allows you to play a single Action card non-terminally at the start of every turn, as long as you choose Frog for one of the two plays, similar to Prince, although with a few obvious differences

Citadel + Way of the Turtle does the same, without taking up a space in your hand. (Also, if you play it using WotT the first time, you can play it normally without it being in play, which can matter in some rare cases--e.g. Imp, Conclave).

[Awaclus]

There are many ways to cheat a Siren into your deck without trashing an Action, but Sailor + Siren is pretty unique in that not only does it let you cheat a Siren, it's an entire strong strategy on its own: the fact that Sailor trashes before Siren draws gives you powerful hands to hit $8 (and beyond), the fact that Sailor gives dollars contributes to that as well, and the fact that Sailor thins your deck means that your deck doesn't really even get bloated by the Provinces until you have gotten rid of most of your starting cards (if you trash a Copper and buy a Province, your deck stays the same size, and that is a pretty typical turn to have).

Baseline strategy assuming you aren't getting contested (almost certainly not optimal, but it is a starting point): Just open Sailor/Silver, buy a Siren when you draw Sailor and use Sailor on it before it trashes itself, buy another Sailor with the ridiculously high-$ hand you will have after that as silly as it feels to do so, buy a second Siren when you get the chance, and then buy Province if you can and something to help your economy (like Gold or more Sailors) otherwise. 5/2 is a bummer but Sailor/nothing is probably the best opening there. Many things that help you hit $3P for Familiar are also useful here, because the scenario is similar in the sense that you're trying to connect three dollars with a specific $4 card, although Sailor can be drawn dead.

If you draw $3 with Sailor on turn 3-4, you can probably get to 4-5 Provinces in about 11-12 turns while dealing out almost all the Curses and being immune to discard attacks.

[allanfieldhouse]

Spell Scroll + Treasurer -- instantly empties the Treasurer pile and gives you $30.

Spell Scroll trashes itself to gain & play a Treasurer, which can pull the Spell Scroll back out of the trash into your hand (and net $3 each time). Repeat until the Treasurer pile is empty.

[mxdata]

Spell Scroll + Treasurer -- instantly empties the Treasurer pile and gives you $30.

Spell Scroll trashes itself to gain & play a Treasurer, which can pull the Spell Scroll back out of the trash into your hand (and net $3 each time). Repeat until the Treasurer pile is empty.

You'd need a bunch of extra Actions to make that work though. Treasurer doesn't play the card it gains and Spell Scroll is terminal

[AJD]

Spell Scroll + Treasurer -- instantly empties the Treasurer pile and gives you $30.

Spell Scroll trashes itself to gain & play a Treasurer, which can pull the Spell Scroll back out of the trash into your hand (and net $3 each time). Repeat until the Treasurer pile is empty.

You'd need a bunch of extra Actions to make that work though. Treasurer doesn't play the card it gains and Spell Scroll is terminal

Spell Scroll is a Treasure; you don't need an Action to play it.

[mxdata]

Spell Scroll + Treasurer -- instantly empties the Treasurer pile and gives you $30.

Spell Scroll trashes itself to gain & play a Treasurer, which can pull the Spell Scroll back out of the trash into your hand (and net $3 each time). Repeat until the Treasurer pile is empty.

You'd need a bunch of extra Actions to make that work though. Treasurer doesn't play the card it gains and Spell Scroll is terminal

Spell Scroll is a Treasure; you don't need an Action to play it.

Oh, right. Momentarily forgot it was both an Action and a Treasure

[mxdata]

Extra turns can be a good way to get your Landing Parties back into play. I had a game with Outpost and Landing Party, and since you often can't do much with an Outpost turn, you're often not losing much going straight into your Buy phase. Voyage would probably be an even better card to have with that

[mxdata]

Buying a Mint with one or more Jeweled Eggs in play. Easy way to get a Loot early on!

[mxdata]

I didn't find this, but I had a game where my opponent used it: Taskmaster + Swap, as long as there's at least one other $5 action card available - you can simply Swap out one $5 for another, and since Swap uses "gain" rather than "Exchange", that keeps Taskmaster in play.

[J Reggie]

So swamp shacks and black market was really fun.

[mxdata]

Hasty Tormenter is interesting. If you have no Duration cards in play, it's almost like getting an on-gain Imp (just delayed one turn from the usual on-gain effects). If there are Duration cards in play, it's like an on-gain Hexing

[Gherald]

Kinda obvious but Trickster/Encampment works out well

[Kingreaper]

Siren + Band of Misfits is well worth it, even in the rare case that that's literally the only card that Band of Misfits can copy; the pile isn't going to get emptied in most cases, so you've just got a $5 Siren.

Obviously having more flexibility on your band is better, but $5 for a curser that draws you to 8 next turn is still a good deal.

[joefarebrother]

Shaman forces a player to gain a card on their turn; so it can trigger blockade. In particular, if you blockade a curse, and ensure the trash consists of exactly a curse, you can make the next player gain all the curses!

[mxdata]

King's Cache + Tools is ridiculous, since you can obviously use the Tools on the King's Cache itself, meaning that whichever player is able to hit $7 first can easily end up getting most of the King's Caches

[mxdata]

Remake + Jeweled Egg → Remake Jeweled Eggs to get Loot and some $3 card, and then later remake the Loot into Provinces

[mxdata]

Fated is great with cards that you want to play multiple copies of. I had a game with Fated on the Idol pile - the Curse pile ran out pretty fast in that game!

[mxdata]

Shaman weakens most trashing attacks, but Corsair actually becomes stronger with Shaman in the game - you can get the cards Corsair trashes

[grrgrrgrr]

Reckless Crew
This thing does NOT have to return to the supply. Like at all.

Nearby Peddler
Dear programmers of Dominion Online, please prevent this one from popping up. (I've not encountered this one, but I dread the day I will)

First Mate + Nonterminal trasher
Trash stuff, then draw back to make up for the reduced handsize. First Maid can be quite nuts for sure.