From what i know about the meme, most of the time he comments on ridiculously un-dangerous things like putting Q-Tips in your ear even though it says not to do so on the box, or removing an USB stick without disconnecting it first. In the movie on the other hand, he does something that's not just dangerous but a forced loss. So i think the meme can be applied in a variety of ways.
By the way, i remember doing something like "I see you go for Rebuild on a Shelters board", which sparked a pretty similar discussion.