Laughing too hard to think of edge case (just realized, there is no edge case).
Opponent trashed deck down to victory cards and Scout!
You could go Harem-Nobles and then trash all of your non-Victory treasures with a Chapel or something. Your Scout would have just one non-Victory card to avoid, but if you got too many Nobles, you could theoretically draw your whole deck except for Chapel, so as long as you don't get that many Nobles, it's ok.
Though if he's ever played a Scout game other than this occasion, he can probably make this statement about his life as a Dominion player. And he probably doesn't have an awesome second half of his statement tomake.