I have asked on a T1 misclick (discarding my $5 opener) when I tabbed back into Dominion if they would be willing to just wait until T3 to actually start the game (i.e. neither of us buy anything until T4). When they refused I resigned because they clearly cared much more about points than I did.
I will tell my opponents about misclicks, not so much to get the win, but so we can, maybe, try to mitigate the click and undo the damage if they want a challenging game more than the win. E.g. I have had and have offered to opponents to buy nothing this turn when we are both drawing deck when they misclick & play draw before village.
Winning is far less interesting than a challenging game, but at least the interface seems to be improving so this isn't as common.