Why not Alchemy?
Anyway, welcome, I didn't notice it for a while too.
I guess alchemy just has a bad rep for being less applicable in all random games, which I absolutely don't agree with. Just as mountebank is almost a must buy in any game it's in, One should consider Potions a must buy if the single Alchemy card is vital to winning. This is most often Familiar, but often Scrying Pool, Apothecary, University, Vineyard and Alchemist can fit this as well. One shouldn't judge potions based on the number of Potion cards in the kingdom. Potions should be evaluated in regards to how useful it is to obtain the cards available (even it's a single card) with potion in their cost.
Alright, my rant on Alchemy is done, hopefully people will see this and reevaluate their less than stellar opinions of Alchemy.