In a Pandemic: On the Brink game two days ago, I came across an unusual and incredibly specific combo, whose benefit is pretty minor.
For reference:
Troubleshooter - looks at the top infection cards at the start of their turn, reveals cities to direct fly there
One Quiet Night - skips the infection phase this turn
We were playing Bioterrorism challenge, and it was the troubleshooters turn. I saw the top two cards of the deck, and there was a problem I couldn't fix, a big one. So I used One Quiet Night. In the course of the turn, I ran into the Bioterrorist, and with one somewhat spare action captured him.
Then it's the Bioterrorist's turn, and suddenly they've got a pretty weird choice to make. Do they draw one and escape - but I know that top card is possibly bad for me if I draw it considering I OQN'd it. So maybe they pass instead? If they do draw it, I also know the next top card, so the probably just want to escape. But maybe I saw that the city they would escape to is awkward, so they might draw twice... And I know the second card as well.
Ultimately the mind games sound far more complex than they are, but it's definitely an unusual way to deal with a problem as the troubleshooter. "Yeah, so there's a big issue with Shanghai, looks like we may have an outbreak there soon. So to prevent it I'm going to drive to Cairo and capture a Bioterrorist."