Nobody will tell you you should be worried about Miniaturization, so that's safe.
You should be worried about Self Service, though, and almost every 10 actually. AI is probably the weakest beyond Miniaturization, but even that you have to be aware of with Robotics and Software.
Self Service, Bioengineering, and Globalization can all instantly win the game.
Robotics and Software are similar to and sometimes more powerful than The Internet since they draw, meld, and execute the other 10s.
Databases can singlehandedly wreck your opponent's chances to get a crucial last achievement.
Stem Cells, particularly if it follows Fermenting/Paper draw shenanigans, can give you enough score to grab all the standard achievements.
AI and Miniaturization are both really weak, but at least AI makes you be more careful with draw/meld/execute cards. And I've seen it used to win the game deliberately when an opponent has a much higher score.
So basically, anytime someone hits age 10 all bets are off. Internet exemplifies this well, but it's hardly the only one there. I will give you that it's the one I'm never unhappy to draw, but that's also true of other cards from earlier ages (say, Industrialization or Machinery).