There should probably be a thread to discuss, "what would you do in this specific situation"? So, lets use this thread.
I had a tough choice today:
I have Mathematics and The Wheel on my board (as my only top cards). The 1 pile was depleted (mostly into our score piles), the 2 pile had 6 cards. Fermentation was either in the deck, or was the "2" achievement. I had Currency (age 2, one leaf) in my hand.
My choice: keep drawing with the wheel, to hopefully grab fermentation? Or start teching with Mathematics?
Things to consider:
There is a 1/7 chance fermentation is not in the deck
Icons: I had no leaves, but my opponent only had 1 or 2. (Most of them were in the various score piles.) I could control leaves once I got fermentation, but I would have to take meld actions to do so.
Math: I already had the 2 in hand, ready to go.
My decision: I went with Mathematics. Would others have done differently?