Not sure if there's any article covering this already, but...
I can't put my finger on where, but I've read somewhere that if there's a dominant $5 card, and you want to the best possible chance to get it on turn 3 or 4 after a 3/4 opening, that opening should just be Silver/Silver on most boards, or Silver/virtual-Silver (e.g. Militia).
What I'm wondering about is: what if that key card costs $6, but you're still looking to buy one or two ASAP? Turn 3/4 is less realistic for $6, but does anyone have words of wisdom for increasing your chance of getting $6 on the second reshuffle, i.e. turn 5/6?
Example strategies where this might come up include BM + Hoard, BM + Goons, Border Village + Cultist/Torturer/Rabble/etc (in that last one, I've noticed that if both players get their first attack on the same shuffle, but one buys it at 5 and the other gets the free village, the player with the village usually wins, especially if the attack is Torturer).
I guess if there's some consensus out there about how to do this, I'll compile it into a real article. After we get there, it might also be worth considering other spending points. Like what kind of openings lead quickest into decks built around King's Court? Or how do you build an engine where all the pieces cost $4 or less, so you're not immediately worried about hitting $5?