My standard setup:
Tra Cur
Cop Sil Gol Pro Duc EstWith two or three rows of Kingdom cards below them, grouped by cost, in alphabetical order within each cost group.
If Plats/Colonies are in play, they go between Gold and Province.
If there are other special cards in play they go in the same row as the Trash and Curse piles. I move Trash to the center, move the Curse pile above the Trash pile, put special treasure cards (Potion, Spoils) above the main treasure cards, and other special cards (Mercenary, Madman) above the main victory cards.
I normally play 3P. One person sits directly in front of the setup and can read the cards head-on. The other person sits on one side but has the blue randomizer cards set up near her, reflecting the kingdom card setup on the table, so she can easily review the setup without twisting her neck. I sit on the other side and just tough it out.