As you may have noticed in Dominion, there are certain cards which can do some pretty neat things, but you usually don't want too many, and you'd rather spend your turns getting better cards instead, especially since most of them are not just game-specific, but turn-specific. They tend to be on the cheap side. So what Band of Misfits lets you do is play them without having to buy them, exactly when you need them, and then be better cards when necessary. Examples might be Smugglers, Trade Route, or Herbalist. Like Trade Route, but didn't want to spend a turn buying an Estate? Well, once Provinces and Duchies have been bought, make Band of Misfits a Trade Route, and let it do its powerhouse thing without having to worry about colliding it properly. And how many times have you had a Smugglers in hand when your opponent only buys a Province? With just Bands of Misfits, you need only have a Smugglers when he picks up a Gold or Grand Market. And ALWAYS make sure that Potion goes back under your Alchemist stack.