Feature requests, from a total newb's perspective:
As the player list refreshes, anything you are typing into text boxes disappears. I often like to set up solitaire games with specific card sets, so it gets a bit frustrating trying to type in the box as it constantly refreshes. Being able to stop the auto-refresh, or a page specific to setting up solitaire games would be nice.
I'd like to restrict to certain sets, the "bias" is just that, just a bias, but I'd like actual restrictions. I am okay with these restrictions meaning the game doesn't count towards your rating. As a newb, I just would like to focus on the older expansions.
I'd like it if your veto only applied to 6 cards not 12 (each player seeing a different half of the proposed board). That way you do not see the whole board. Right now, I think people are vetoing with full knowledge of the board, so it really reduces the "oh, oh, didn't expect that combo" when the game starts, which I feel is an important part of the game's appeal. I like veto games, but feel the ability to veto on all 12 is a tad strong.
Chrome Extensions - Do they exist yet? A list of add-ons that compliment isotropic would be nice.
My apologies if my suggestions are neither feasible or useful to long term players.