As we learn to play dominion, we go through several phases regarding chapel. Initially, we ignore it, since it's a $2 card and we usually have more than $2 to spend and we want to squeeze all the "value" out of our money. Or we only use it to get rid of curses or something since why would you want to trash anything else? Then, someone in our play group discovers that if you trash all your starting cards, you can actually make your deck a lot better. Then we love it and buy it every single game. Then we over time start to realize that it's not really that good all the time. It is one of the best cards if you're trying to build some sort of engine that requires a high density of specific action cards, because it gets rid of the fluff, but if you're just buying money, chapel big money is worse than straight-up big money. You spend your first few turns trashing, run really smooth for a brief period of time, and then choke on green cards and end up losing by a couple estates to the guy who just has a ton of silver which allows him to have a better money density than you.
The important point is that chapel enables some good strategies, and is not itself really the backbone of any strategy. It is the single best trasher in the game. But trashing is not a strategy in and of itself. It's an early-game tactic which leads well into specific kinds of mid-games. I think guided hit it on the head: you shouldn't think of chapel as a default opening and think of "alternatives". You should be aware of its presence when you choose a strategy and be more willing to play strategies that require heavier trashing. Probably 80+% of the time the best strategy will be one that uses chapel's trashing. But sometimes there are no really good action chains to be made, due to lack of villages, +buys/gains, or something else, and there are fast no-trashing or lighter-trashing strategies that can get half the provinces just as fast (while having an advantage in estates).