I can't understand why anyone would want to play a good board game or card game on the computer instead of in real life O.o One of the major appeals of tabletop stuffs to me is the tactile aspect: in Dominion's case picking up cards when you buy them, putting down cards to make action trees when playing actions in an engine, picking up victory point tokens or trade route tokens for the mats, seeing and feeling your deck grow as the game progresses. All of that is just SO much more satisfying than clicking on some screen with a mouse. Similarly there's actually tension when using cards like Golem because the results aren't instantaneous: you have to reveal cards from your deck one at a time, whereas on isotropic you get shown the results of the Golem instantly which is nowhere near as fun as cycling through your deck one card at a time wondering what will be next, hoping you'll hit that Torturer or dodge that Bishop.
The only reasons I play on isotropic are for the challenge, because I don't own all the expansions and because I can't play often enough in real life due to others not being as interested in tabletop stuff as I am. But in every other possible way I can think of real life Dominion is preferable to isotropic (well, except Philosopher's Stone
).