I don't really have much time to play on isotropic (and when I do, it's just with friends) but I tend to spend spare minutes zipping through games on Androminion. I'm still fairly amateur but I feel like I know enough to come up with a decent plan on most boards, if one exists.
Playing on Androminion, I ran into a set where I really didn't know what to prioritize:
Scrying Pool, Philosopher's Stone, Familiar, Swindler, Tunnel, Tournament, Margrave, Library, Venture, Adventurer
Library doesn't seem all that great to me here. It would sort of counter Margrave, but the only source of +Actions is Trusty Steed so you can't turn it into an engine. Similarly, I don't really like Swindler here because I feel Margrave and Adventurer are both better to have as terminals.
Venture and Adventurer looks like a really fun combo, and Tunnel looks really attractive due to Margrave, Venture and Adventurer; it could actually end up a fairly consistent source of Gold. Throw in Philo Stone and there is a very real chance of double Province turns. Margrave would be the main source of +Buy but it's terminal. There is also Princess, where the price reduction effect would make those big money turns even sweeter.
Since I think this is more of a Money kind of board, Scrying Pool doesn't seem all that great. I still want the Potion though, because Familiar will be important and Philo Stone can be great later on. If I'm unfortunate enough to hit 2p instead of 3p, Scrying Pool is an alright consolation prize since it helps power up Philo Stone and it is a cantrip at worst.
All that said though -- I have no idea what to prioritize. On a 4/3 split, Potion/Silver? Would Swindler actually be a decent opening? I can see Swindler being useful to turn Coppers into Curses even before someone gets Familiar, and also potentially changing Familiar to Philo Stone early (and back again late, when Curses are out). I still think Silver is better though.
On 3, Tunnel or Silver? I suppose there's no point grabbing a Tunnel until the opponent picks up a Margrave or you have an Adventurer or Venture.
On 5, should you take Margrave or Venture? One Margrave and then Ventures after that? Two Margraves?
On 6, Gold or Adventurer?
How many Familiars should be bought and when should I switch over to Philo Stone?
Given the synergy between Adventurer and Venture, and the fact that Philo Stone can be worth much more than Gold, is there a point when you'd rather not reveal Tunnel for Gold?
And finally, when you manage to align Tournament with a Province, would you prefer Princess or Trusty Steed? Or Maybe even Bag of Gold to get more cards in the discard for Philo Stone, and to top-deck Gold for Aventurer/Venture? I believe Diadem would be useless given lack of +Actions cards, and Followers would be redundant with Familiar and Margrave.
A lot of questions, I know, but I'd be really interested in insights.
Thanks!