Recently played an in-person 4 player game, believe the kingdom was:
Masquerade, Loan, Trade Route, Silk Road, Salvager, Bishop, Hunting Party, Horn of Plenty, Cache, Expand (W/Colony & Platinum)
All had 3-4 opens, I had first and went silver, saw 2 people buy Bishop so figured I would go Masq to get some drawing w/my trashing (VP from Bishop was not going to be a factor). Plan was to rapidly trirm deck while leaving a couple junk card to pass in case of Masquerade, then go HP+Expand+BM. Worked pretty flawlessly, With 2 HP's (really should have had a 3rd but didnt matter), was able to play my Expand most turns later in the game and ended up with 6 Colonies (last turn I Expanded Plat to Colony+bought last Colony to end it.
Skill level was varied here. Some players were kind of unfamiliar with certain cards and made some otherwise questionable decisions. One player bought a Cache?!? and afterwords said he figured he could trash the copper for VP with the Bishop (poor choice for this deck and 1 VP is meaningless in a Colony game). HP would have been a much better buy here IMHO. Another played bought a Colony too soon IMHO, which was later Bishopped to get the +1 coin he needed to bu another Colony. Not sure if that was a good move here. I think the rest of the group was too drawn in by Bishop here because your acceleration every elses deck here. No was else bought Expand until too late IMHO also.
For the record i dislike 4P games, especially with cursing attacks and limited trashing ability. I too poorly in those for one, and they seem to be more luck dependennt unlike here where you can really plan an engine.