Since there are so many posts about poker, I'd like to ask, in poker what do you mean by playing a hand perfectly? In my limited understanding to the game, does the game not rely more on reading your opponents, once every player knows well about the probabilities?
Also, I would imagine the luck of draw matters less in a poker game, since the play is by nature adjusting your bets to your draw. Sure there are irritating moments when you ought to win by chance, but the opponent just drew incredibly, but this happens in every game that involves luck.
The problem of dominion, in poker terms, is that I cannot fold when I didn't draw my chapel at turn 5, or when I see my opponent get a turn 3 Forge, or when I draw 2+P turn 3 with the only potion card being Familiar. At least I think that is unsporty. Also, resigning early is still a loss, I cannot leverage it by "folding" early. In these games, if you are on the unlucky side, you start to fight against the odds; if you win, sure that's a good feeling; but you are going to lose the majority of them anyway if your opponent plays normally. If you lose, congrats on wasting another 10 minutes proving that a large portion of the game is determined by the initial draw.
And even if you are on the lucky side, the game becomes boring once you start to understand the luck. You will know that your opponent just lost because you were lucky or he was unlucky. Again, while winning in the end can be a better feeling, still you wasted your 10 minutes showing that you can play normally.
I may be exaggerating a bit, but I think this is the intrinsic problem of luck in dominion.