Played IRL with Alchemist, Scrying Pool, Lookout and Margrave. We both like drawing decks, so I opened silver/potion while my friend opened lookout/potion. I got a Margrave first (and my own lookout), and off we went. My margrave hit early and often while we both collected alchemists and scrying pools. I won.
Checked with the simulator, turns out lookout is somewhat of a dead card here. Better to just open silver (55 - 42) like I did and get an early margrave & money lead (and skip the lookout), supported by card draw.
But guess what dominates both? Margrave + BM (75 - 22). Take that Alchemist.
Lesson learned: be wary of Alchemist. A shiny distraction at times, for sure. Being forced to discard your alchemists will make you sad.