So a reliable source (my personal speculation) tells me that there is going to be a Dominion Board game. But how would such a spin-off work? I'll tell you how: I have no idea!
Ok, joking. I have some idea. Here's what I'm thinking: Players having their own pawn on a board. On your turn you can spend an 'action' moving from one space to another. You then activate the power of that space. You can then buy cards, add them to your deck. When you play them, they go on the board in an available space adjacent to your kingdom. The cards themselves would be tweaked, but +1 Action can turn into 'Move to an adjacent space'. So building a bunch of laboratories on your turn can be 'chained' by moving down the line.
Probably will never happen, and if it does it would be much more cleverer than my idea. But who (besides DXV) knows. So, what are your ideas?