I cannot see this card doing anything worthwhile in a Scrying Pool deck. First off, I would be buying Pools with every Potion buy, and besides, what benefit is it to fill your deck with terminals (as replacement for coppers) when they are basically useless en masse? Yes, obviously it is important to clear out the starting cards to make a Pool deck work, but I would require a better trasher to begin with before I went this route.
Personally, I hate this stupid card. As bad as I think one instance of this card is, I cannot stomach the fact that the dumb thing replicates itself like gremlins in a swimming pool. With just about any other Potion card on the board I would buy however many of those I would like and then hope to find a way to get rid of the Potion.
As stated above, with Pools I want as many of those as I can afford to spend Buys on. With Golem the thing is a cancer. It is counterproductive with Vineyards unless you really want to completely destroy your buying power down the stretch by infesting your deck with a bunch of these. University? Okay, it doesn't actively compromise a Uni but you would think there would be better terminals to pick up for free. I can't see buying Transmute over an Alchemist unless I decided to boost someone else's ladder rating.
By itself? Great, now I have two crap cards in my deck!
I tried to make this card work on BSW with little success, so I haven't used it on Isotropic in any significant way. I have found uses for the Chancellor, Ironworks, Spy, Workshop, Adventurer, Woodcutter, Scout, Mine, Smugglers, the two copper spells, Pirate Ship, and Explorer; these are all substandard cards and require a just cause to validate buying them. Bureaucrat, Thief, Pearl Diver, Navigator and Herbalist are all skipped without some half-crazy plan. Contraband and Transmute? I don't even see them... it is like playing with nine kingdom cards.