It seems like the main benefit in your mind of 2es is removing unfun cards from the pool. Aside from Alchemy and the Doom cards, are there any cards that you haven't gotten the chance to remove via 2es, that you wish you could remove?I can't give any assessments of the future, and also it's not so clear that "haven't gotten a chance" really applies.
There are certainly a few cards I'd tweak or replace that aren't grouped with a bunch of others in the same set, so that a 2E wouldn't be so great to do. I do talk about them some, in contexts that are less like "tell us what 2E's are coming."
"Haven't gotten a chance" I would think includes cards in sets that already have 2es, and cards in sets too new to want 2es. Like, if update pack size weren't a concern, would you have dropped Merchant Ship for Seaside 2e?