What are your thoughts on the large skill gap in Dominion? While clearly Dominion appeals to heavy and casual players alike, it can be difficult to casual players to enjoy games with heavy players.
It's not a problem I have had personally, though I wouldn't be the best data point. The goal as always is that the game is fun to lose, and in my experience it is.
I do have the problem of a good player who is also slow. Another player leaves when that one shows up (which is always later in the evening). The problem isn't that he's good though, it's that he's slow. Draw your deck quickly, that's my advice. You're already winning, you don't need to eke out each conceivable grain of advantage. On my side there are cards I've blown it on there, like Scrying Pool, and well sorry, and you can skip them if someone is going to hate the slow game.
In games irl with no horribly broken didn't-make-it-to-print cards, I have seen only a tiny number of resignations, out of thousands of games.
Going into it I knew nothing; for all I knew the game wouldn't work at all. Chaining cards was fun so there is some of that; later sets have more than the original main set, because players at large liked it too, hey why isn't there more of this. I didn't start the premise that some turns would be fast and some long, and it doesn't sound like a good premise; but when we are all having a blast I don't say "no no, this is no good."