Additional note: Online, the message "[player name] plays a Fool" never gets old.
I almost always skip it. I love that Fool comes with a "lucky coin" that junks your deck with super-coppers. I love playing against opponents who play the coin every time they draw it and never trash it. (Also, props to Changeling. Again. For making Lucky Coin good.)
And while some Night cards aren't worth the extra mechanic (it probably wouldn't be worth creating the "Night" phase just for gain-to-hand durations) I really like the concept of cards that only work as night cards because they care about what you did on your turn, such as Monastery, Devil's Workshop, Changeling and Crypt. The others, well, would work just about as well as actions, making their "Night" designation often a drawback for the many, many cards that care about "Action" cards.
IRL players who plunk money down, grab their buys and clean up all in one fast scoop and complain that Night is slowing that down could probably benefit from slowing down their play anyway. Between durations, reserves, clean-up triggers, and just, plain looking at the cards in the play area for a second before scooping and making a mental picture of what's left in the deck, there's something to be said for playing deliberately. I rather like a night card at the end of a good turn. It's like a satisfying terminal punctuation mark at the end of a well-constructed sentence