This may have been asked already, but how do you play IRL? Assuming you're playing somewhere that requires you to take the cards with you, rather than having them right in your living room or whatever: do you just take a couple of expansions with you or do you carry the whole shebang?
I carry the base cards plus either two large expansions, or a large expansion and two small expansions. If it's two large sets I deal out 5 from each, otherwise 5 from large sets and some amount from the small ones. In the Dark Ages days I would sometimes bring it by itself or with one small set.
After each game I take out four cards and add four cards, except when a particular card is staying in because testing is focusing on it.
For the most part if we're playing with Prosperity we use Platinum/Colony, and if we're playing with Dark Ages we use shelters.
In my living room I still just play with 2-3 sets, but Black Market can be a set not being used. In the early days we played with everything, but once I had several expansions I've mostly just played with two at once. Except online, where I typically just forced 3-5 cards from the set being tested, except for games using ten from that set, and the rest are random.