I was actually thinking of having a team game, 2 v 2, combined culture wins.
Eh, 2v2 is pretty degenrate unless you apply some major houserules. All the same problems with 1v1, but compounded by the fact that you can afford to do things like one high/one low military, potentially ignoring otherwise high-priority cards because your second player can grab them for fewer actions, and above all, Pacts.
These are all house-rulable issues, but not necessarily easily so, and not enforceable online, (in particular, the seating should alternate between teams with one team even, one team odd, rather than one team 1&2, the other 3&4, and pacts shouldn't be possible between two members of the same team).
(I speak from experience of having tried it a couple of times)