What about Anti-Dominion? (Game end conditions same as normal, but player with lowest score wins; player with fewest turns wins if scores are tied.)
I'm fairly sure that this just would not work on most boards; maybe opening Remodel/Curse stands a chance of beating Curse/Curse, I'm not sure.
But with the right board, does it have the potential to become interesting? How about this one?
Estates/Provinces
Hamlet, Stonemason, Smugglers, Swindler, Gardens, Messenger, Temple, Worker's Village, Highway, Hunting Grounds
Landmark: Wolf Den
If you like the idea, feel free to suggest strategies for this board, or other 'neat and potentially useful card interactions'.
And I'd recommend you don't try this just before your league game...