I'm doing this in Dominion Online, so it doesn't include Adventures. It's designed around no shelters and no colonies/platinum.
Base: Moat
Intrigue: Nobles
Seaside: Salvager
Alchemy: Possession
Prosperity: Peddler
Cornucopia: Fortune Teller
Hinterlands: Crossroads
Dark Ages: Pillage
Guilds: Soothsayer
Promo: Black Market
I think it will work with any number of players. I like the different avenues this can take. Crossroads/Nobles is obviously the start of an engine, and Peddler/Salvager can help. The attacks can slow down engines, but for multiplayer you have moats to stay sane. Finally, possession and black market are there for people falling behind who need to try something dramatic to change their fortune. Also, Big Money is still an option, but the cards to get there are more expensive. A 5/2 split is pretty strong with pillage. What do you think?