Do you give any thought to the alphabetic distribution of cards in sets? For example, Empires has 7 piles beginning with C, and 2/3 of its cards in the first half of the alphabet. Cornucopia has most of the set beginning with F and H.
(Also, did you have to put Empires in between Dark Ages and Guilds? Those two were sharing a binder page, since small sets take 1.5 pages. Worked well for Alchemy / Cornucopia, too)