Yikes. In a draft, I guess I'd pick chapel first, and if the other guy picked chapel I'd probably go masquerade. Then again, maybe both of us could lose to a Rebuild guy. That's an interesting way to think about things.
Although, I do think it skews things somewhat. A board of guaranteed power cards really benefits King's Court, which more than anything else seems to get stronger the more power cards are present on the board.
So actually, I guess the guy who picked King's Court would be in best shape. Even if his opponent gets some absurdly strong cards, just a couple of the top 20-top 10 in a kingdom with King's Court probably makes all the difference.
Goons is even more frightening than usual. Because only one person can go for it, the other player must find some way to severely impair the opponent via strong attacks or win the game before the Goons guy gets a lead. Once the Goons player is, say, 100 points up, there's nothing the other guy can do to catch up. Maybe Monument or Bishop, but those aren't as fast.
I actually think cursing is less intimidating here. The opponent can strike back with either Masquerade or Ambassador, both of which counter curses quite neatly.
Any other thoughts? Frankly, I suspect that some sort of nightmarish combo would emerge in a format like this.