So I recently got these sims working, and now I'm working my way through the Beat the Bot challenges. It's fun.
I really like Duke/Duchy on this board, but it took a few tries to perfect it. I opened Silver/Forager and tried to reach Altar and BoM. BoM is strong because you can use it as crossroads, caravan, or storeroom, depending on where you are in the turn. But if you don't hit $5, it doesn't hurt to pick up a few copies of the cards it wants to copy.
At the end, every turn I was playing 2 crossroads, 2 caravans, an Altar to gain Duke/Duchy, and a storeroom to buy 2 Dukes/Duchies. I ended on turn 18 with 102 points, and this deck:
[1 Silver, 8 Duchy (24▼), 1 Province (6▼), 1 Altar, 3 Band of Misfits, 2 Caravan, 1 Crossroads, 8 Duke (64▼), 2 Silk Road (8▼), 1 Storeroom]