There isn't a Worst Dominion Moments thread, so this will have to do:
Opening hand: CCEEE
Turn 1: Buy Chapel; draw CCCCC
Turn 2: Buy Relic; reshuffle, draw CCCEE
Turn 3: Buy Vassal; draw CCCCE
Turn 4: Buy Talisman; reshuffle, draw Chapel, Relic, Vassal, Talisman, and Cooper
Total cards trashed, turns 1–7: one