Yeah. Acheivements/items I have left are:
Get 4 meat cubes (aka RNG: the acheivement.)
Common cold (which is also RNG, but I think it's weird I don't have it yet. You only need two items, and they're not THAT rare...)
Beat Sheol with Samson, Eve.
Beat Cathedral with Samson.
Beat Chest with Samson, Eve, ??.?
tl;dr I really do not like Samson. I don't like Judas either, but I just got two amazing back to back runs to Chest and Sheol today, so at least I never have to use him ever again.
Edit: Oh and no damage on depths or womb, but I'm focusing more on unlocking the items than the achievements.
The 4 meat cube ones, having the book of revelations help, since if you use it, you are guaranteed a fight against a horseman at the end of the level (unless you've already fought one in this "zone"). Unlocking the forgotten horseman doesn't help, though.
I hate Samson. He's just the worst of all, with no life, no damage, no tears... I find dead baby is better than him! There are some objects that only activate when you're at half a heart or lower, and dead baby abuses them like no other. And he doesn't get lowered tears and damage either.
But I do like Judas. He's got insanely high damage, and his object is quite nice (increased chance to find Satan, which might translate into an angel room later on if you can't buy anything). He is dependent on finding a couple of heart increases quickly, though, so I can see why you don't like him.
But my favourite is Cain. He's quick, he's strong, and his initial object is nuts, both from the increase of drops, the always positive pills (bordering OP), and the better returns on fortune telling machines for crazy amounts of spirit hearts (which aren't capped, unlike red hearts). Seriously, all this for one less heart than Isaac and slightly less range.