When my girlfriend got me Alchemy earlier this year for my birthday, we opened it up to have a game. I got a couple of Possessions and played one to show her how it works and she got annoyed that I had stolen her turn... as you do. A bit later on she had managed to get her own Possession to get me back. She Possessed me and played my Golem. 2 Possessions. Of course, I had many many other actions in my deck because I wasn't playing as seriously as I do online, and also it was an Alchemy game so there was always going to be actions anyway, so it probably wasn't very likely the Golem would hit a single Possession, let alone two.
After that Alchemy stayed on the shelf for a while.