I hate the interface. That's about it.
For those who say 'it's more like IRL Dominion,' I agree. But IRL Dominion is the inferior version of the game. And for those who say 'it's more appealing to the common fan,' I'm not sure I agree. But regardless, I'm not the common fan, and I happen to hate it.
I can't really imagine spending money to play it that way, even with Dominion being my favorite game. We'll see if that changes once Iso finally goes, but...to me it's just a completely different (and far worse) game.
I find it hilarious that you find what is essentially bug-testing software to be superior to an actual finished product.
It can be reasonably called superior for certain values of "superior."
It's superior for a tournament setting. Any reasonably competitive player would prefer to play a tournament on Iso, and any tournament director should prefer Iso, for two reasons. First, it's much faster. A single IRL Dominion game, including setup time, can take as much as 30 minutes or longer even for 2P; in the time it takes to unbox and set up one game of IRL Dominion, you can play two Iso games if they're fast boards, or one on a slow board. Second, this speed allows for best-of-N formats, which are superior in determining the "better" player--ostensibly the intent of a tournament.
Iso is superior for people who want to study the game of Dominion--which is ostensibly the intent of this blog and forum. Sure, you
could log an IRL game to look at the log afterward, but it's going to be an order of magnitude harder than logging, say, a game of chess.
Iso is superior for those who want to play a lot of games, due to its speed.
But IRL Dominion is superior in other ways. Iso is not exactly a wonderful place for actual social interaction; even chats during and after games tend to be quite perfunctory, even nonexistent. (Goko will have this same problem, if not worse.)
IRL Dominion is also superior if you prefer to play a variety of games. My gaming group gets together for about 4 hours every second Friday; maybe that means a game of Dominion, then one of Power Grid, then one of something new we haven't tried before, or whatever. Iso is great for... Dominion only.
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Given that this discussion forum is for people who like to play a lot of games, and like to analyze their (and others') play, it's not at all surprising that people hanging out here would feel that Iso is better than IRL Dominion.