I recently played a game where these two cards appeared together, they formed an interesting combo.
It's not a straightforward combo as many of the other combos that have been posted are, because it needs some support to set it up. But when the support is there, it's really fun to play.
The main trick of the combo is:
Discard all of your action cards with Secret Chamber (SC) and use Scrying Pool to draw them again. You can repeat this process as long as you have actions, SC's and SP's remaining. Vault can work also, but it's more expensive and lets your opponent possibly benefit as well.
First and foremost you need a Village. SC is a terminal. Villages enable you to play more SC's and they serve as extra draw cantrips when you get them off a SP chain. Border Village is a nice target as you can grab an extra Action card with it. The SC->SP trick only works when you're able to draw your entire deck otherwise you're not guaranteed to draw everything off your 2nd or 3rd SP. This means heavy trashing and/or draw assistance like Lab.
Then there's the +Buy. It's fun to generate tons of money, but you need Buys to spend them. Something like Worker's Village can help here as it provides both the Village and the +Buy component. +Buys also help when gaining Scrying Pools early with cheap action cards like Pawn and Hamlet.
All in all it's an interesting combo, but not one you're likely to come across often, because of the needed support. Still, it's always fun to let a bad card like Secret Chamber have its moment of glory.