Unfortunately, the document isn't working for me, but 1 septillion seems out, unless you included every possible Black Market, which while technically correct, is a bit... blah. If you do, then it's probably right, but an incredibly vast majority are virtually identical games. If you don't, well... I'll do some quick calculations here (all done in head, yes I know I'm sitting by a computer I don't care) (pre-post edit: I didn't see the second and third post while making this, but I think asides from the Black Market considerations nothing really changes?)
Colony/Platinum is simply a factor of 2. Yes or No. So that can be factored in later. Young Witch is in 10/157th's of games, correct? And it has about... uh, 45 cards to choose, give or take? Well, on average about 1/3rd of those are already in game, so about 30. So we need to add on 10*30/157 lots of the games we have, then multiply by 2 for colony/platinum, making about 7 quadrillion games?
Black Market really does add a lot, though. If it's there, then there's 147 cards not in the game which may or may not be in the BM deck, which makes roughly 2^147 ~=10^45ish choices (approximating as 2^10=10^3)? Which actually makes me wonder exactly where your number came from, and I wish the document actually worked ¬_¬.