I think, perhaps, the answer isn't exactly in itself what you're looking for. I imagine most of those responses listed by DG and others, in topics like that aren't generated by a knowledge gained from games played, but from a knowledge gained from hanging around on these forums and reading threads just like that.
I've learned SO many tricks in the puzzle forums for things that are only going to be applicable in 1 in every 10,000 games. If that. Odd pairings that cause unique situations to appear with unusual outcomes is... just different. It isn't about "gameplay" anymore, and really is about "puzzle solving". It's about looking at Dominion through an entirely different spectrum. One that really, most often, has no bearing on the actual game itself.
So I wouldn't worry too much about how being able to come up with crazy things like or not actually effects how you play when you sit down at a table, or join in a game on Isotropic. Most of that is irrelevant. Now, reading and understanding the Articles, and gleaning anything/everything you can from them is an entirely different discussion. And if you were to ask how long you would have to play to be able to think, articulate, and write a comprehensive article on good play/combo's, then I think you would get a very different response than above. One that I am certainly unqualified to answer.