So there are 26 cards that require interaction of the opponent in your turn, if I didn't miscounted. Of course you could play Dominion without all Reaction, hand-size attacks and a few others, and by the rules it's still Dominion. But banning two entire types of card and 1/6 of the pool is somehow strange for an official variant.
Without banning them, you expect at least 1 of these cards to be in each kingdom (having none of them in a kingdom is something like 15%). Some of them are not really bad, Contraband isn't bought that often. Hand-size attacks usually only work once per turn, so you only double the turn length, but Scrying Pool/SC is really really bad.
But what seems unfitting for me is that I might have to wait in my turn. I should somehow be playable in one turn, and I shouldn't wait in the middle of it for 1 to infinity times just because I played a Militia, or because my chain consists of attacks and my opponent might reveal a reaction.
Of course one can try it, but I don't really see it feels natural, so I don't see how that should be priority when you implement the game.
Maybe it should be more important to do a native iOS-app first /scnr