Unexpected little combo I came across in recent game.
Context: The only chaining in the deck is from Apothecary and Alchemist. On any given turn, could only play a total of 2 terminal actions. (due to the event citadel enabling +1 extra action). You already own at least a gold, and a spices, and are roughly chaining your deck.
Execution: Dismantle a gold into a spices (giving +2 coffers) and a gold. Then Catapult a spices. This curses your opponent and forces them to discard down to 3.
Net Effect: +2 coffers, +1 coin and the brutal attack of opponent gains a curse and opponent discards down to 3. Interestingingly, this dismantle + catapult play is similar to playing 2 giants. The economy is a little weaker. (+3 coin instead of +6) but the attack is much stronger IMHO. This combo always forces a curse on opponent AND makes them discard down to 3. Giant only sometimes gains a curse.
Optional Econ building step: Adding a middle step of dismantling the spices to a gold + silver - and then catapulting the silver instead, allows you to gain a gold out of the sequence. so Dismantle, Dismantle, Catapult = Gain a gold, +2 coffers, +1 coin, opponent gains curse and opponent discards to 3.