If Supply cards with Heirlooms are included in the Black Market, should the Initial Desk Coppers be replaced with their corresponding Heirloom?
This same question Principle goes towards any other cards that require 'Setup cards', such as Vampire/Bat, etc.
My guess is Yes.
But the Black Market Rules Clarification section has a few statements that this might not be 'recommended' setup for Black Market (and that I would be playing a 'variant')
It states '... It does not include cards with an obvious setup that would give away what's in the Black Market deck...' This statement makes me feel that the 'setup' of having the Heirlooms would 'give away' that the Heirloom's 'origin' cards is available in the Black Market.
But as a counterpoint to that statement is states '... All players can see which cards are placed in the Black Market deck before the game begins...', so in this section since there an ability to 'see' the Black Market deck, there is no limitation on avoiding 'giving away' the fact Heirloom's 'origin' cards are in the Black Market.