Thanks for all the suggestions and good ideas. This is what we ended up doing -- everyone seemed to have a great time and find somewhere they had fun playing.
Table 1 was just the base set. This one probably got played the most all night. Possibly because the games were quicker, but I also think because some of the guests were more inexperienced than I had realized they would be. After the initial setup, they would just swap out 0-2 cards between games.
For table 2 I set up the Area Control predefined sets for Empires/Adventures (Capital, Catapult/Rocks, Charm, Crown, Farmers' Market, Coin of the Realm, Page, Relic, Treasure Trove, Wine Merchant, Banquet, and Keep). This table was such a draw because most of the experienced players we had over had never played with the newer sets so they all wanted to try it. They were longer games, but everyone who played it loved trying out the new stuff (i.e., Traveller, Split Stack, Event, Land Mark, Tavern Mat). We never modified this table at all.
Table 3 was set up so the people who were familiar with the older sets could have more variety, i just had 5 cards each from Intrigue, Seaside, and Prosperity, and then rotated through the three different combinations (i.e., 5 Intrigue + 5 Seaside; then 5 Intrigue + 5 Prosperity; then 5 Seaside + 5 Prosperity). This also worked just fine.
Before we started, I had planned on doing entirely different set ups on tables 1 and 2 between games, but I realized that really wasn't necessary. I think if we do this again (and from feedback given, I'm sure we will). I'll just set up 3 tables and then not even mess with them. For those who wanted more variety, I found they just needed to move to a different table.
Ultimate lesson learned — Dominion really does have something for everyone. Well, everyone who likes playing deck-building games, anyway.

Bonus lesson learned — I had avoided Alchemy (for reasons that can probably be guessed), but quite a few people asked about it specifically — so it's not as unpopular as some might think.