I think it's more when you'd open with a $2 on 4/3 where 5/2 becomes really crazy. I think an okay 4/3 opening against a $5/- nothing opening will tend to be evenly matched. Now make it a $5/Chapel, $5/Raze, or $5/Page opening and it starts to get iffy for the 4/3.
For what it's worth, I think Exorcist tends to be another really solid opener on 4/3.