Answering the OP, I can think of 2 ideas, though I've not fleshed them out with particulars:
1. 50 Develops:
a) loses on a board with no 4's (and no 2's: 10 estates for the first 10 turns, or waste 'em all...yay!)
b) probably easy enough to make a board with some decent synergies that it can dominate.
2. 50 Upgrades:
b) This would quickly take a board with Border Village and Duchess. (ooh 2 turn win
)
a) I think the easiest way to make it likely to lose is the Ironworks-Island-Great Hall board, also with no 6's and 7's. After the first 5 turns you have 25 upgrades, and all the golds. Of course some lucky gold colisions could get you in the VPs, but you're upgrades are gonna be clogging things for at least a few more turns before you can reliably get good stuff going on.