I personally am kind of hoping for an unlikely Dominion: Rebuilt.
I'm not sure how it would work exactly, and it's probably a very bad idea money-wise, but I can dream. A set with Feast for 2$, some sort of working Adventurer and Thief, a Rebuild that doesn't suck, Cultist with an "or" clause, errataed Possession, fast Scrying pool, cheaper Familiar, maybe even all of Alchemy rebuffed plus some.