I had a league game yesterday where my opponent and I were playing a mirror, the only difference being is that I got an Apprentice. I ended up winning running away. Early on you can just trash your estates, but later you can trash a card costing 4 or 5, even if it's something you still want in your deck, to guarantee a strong turn. Hopefully if you have some kind of +Buy in you deck, you can make up the difference and get that trashed card back.
Apprentice is my favourite Alchemy card, I always look for a way to add one or two to my deck. And Apprentice Market Square is definitely a thing. Wait until your deck gets really thin, and then start going for Gold. Your first Gold turn you could get 12-15 (or more!) Gold in hand and a few buys, depending on how many Market Squares and Apprentices you get. It's not quite Hermit Market Square, but its close.