One could construct such a scenario with endgame pile-dancing for sure.
Sounds cool. Of course, there has to be some information-hiding; otherwise it's no mixed-strategy-situation. Gear could do that information-hiding.
Here is an example without using any kingdom cards. Suppose my deck and hand combined consist of 5 Gold, 1 Silver, and 3 Estates(we both know this), there are 3 provinces and 2 colonies left in the supply, and I have 3 Gold, Silver, Estate in hand (8 coins next turn, 11 this turn). We are tied on points, but you went first and you have a deck with +buy but no attacks. I reason that you have a really good chance of being able to get a colony, and a decent shot at being able to pick up an estate with it. No chance of double province, high chance of double duchy.
If I buy a colony: You have a decent shot at winning with colony/estate
If I buy province, not playing a gold: You can get a colony, taking a commanding lead, but may reason that I am likely to have a colony hand and so settle for double duchy.
If I always buy the province in this scenario, then I do poorly because you are likely to get the colony anyway. If I always buy the colony, you will always correctly get double duchy when in this scenario. You, seeing that I kept a card or two un-played, will have to adopt a mixed strategy to avoid me being able to take advantage of you; and I will also take a mixed strategy in this case. The example here isn't perfect, but hopefully you can see the potential.
As you can see, the information hiding is built-in by having hands and not being able to search through opponent's discards.
I think you can adapt expectiminimax to deal with hidden information. For instance, see
https://en.m.wikipedia.org/wiki/Partially_observable_Markov_decision_process
For simultaneous moves, a mixed strategy can indeed be the optimal strategy. So in either case I'd still take issue with the adage. But help me out here: Where in Dominion do you make simultaneous moves? The only case I can think of is masquerade, and I have to think about that, but my gut reaction is that you could come up with an equivalent non-simultaneous way to express what you do there.
In this case it is effectively simultaneous because you make your decision without knowing what decision I made, that is, whether I chose to not play a gold or whether I didn't have one.
This is also why the real pros don't play all their coppers on the opening when they aren't going to use them. Note that this is completely false; nobody actually does this and it never actually matters even slightly. In theory it totally could though!