I feel like there should be an article about this - probably not citing specific cards that much, but mechanics and such.
There's something to be said about doing things on your last turn that you would almost never do any other time - trashing your last key card, passing your opponent something good, buying 30 coppers, etc. And it's because you know it won't hurt if you mess up your deck, since you won't need to use it again.
Thoughts?